Comparison of Different Drug Susceptibility Test Methods To Detect Rifampin Heteroresistance in Mycobacterium tuberculosis
نویسندگان
چکیده
منابع مشابه
Comparison of different drug susceptibility test methods to detect rifampin heteroresistance in Mycobacterium tuberculosis.
We compared the efficiencies of different drug susceptibility testing methods in detecting rifampin (RIF) heteroresistance in Mycobacterium tuberculosis. Our data revealed that the broth dilution method found more resistance than MGIT did (P=0.046) for the low-resistance group. Similarly, the broth dilution method was more sensitive in detecting RIF heteroresistance in subpopulations with low g...
متن کاملComparison of different drug susceptibility test methods to detect the 1 rifampin heteroresistance in Mycobacterium tuberculosis
23 We compared the efficiency of different drug susceptibility testing methods to detect 24 the rifampin (RIF) heteroresistance in Mycobacterium tuberculosis. Our data revealed 25 that broth dilution method found more resistance than MGIT (P=0.046) for low 26 resistance group. Similarly, broth dilution method was more sensitive to detect RIF 27 heteroresistance in subpopulation with slow grow r...
متن کاملMycobacterium tuberculosis strains with highly discordant rifampin susceptibility test results.
The objectives of this study were to investigate the origin of highly discordant rifampin (rifampicin) (RMP) drug susceptibility test results obtained for Mycobacterium tuberculosis strains during proficiency testing. Nine Supra-National Tuberculosis Reference Laboratories tested the RMP susceptibilities of 19 selected M. tuberculosis strains, using standard culture-based methods. The strains w...
متن کاملDigital PCR to Detect and Quantify Heteroresistance in Drug Resistant Mycobacterium tuberculosis
Drug resistance in Mycobacterium tuberculosis presents an enormous public health threat. It is typically defined as >1% of drug resistant colonies using the agar proportion method. Detecting small numbers of drug resistant Tb in a population, also known as heteroresistance, is challenging with current methodologies. Here we have utilized digital PCR to detect heteroresistance within M. tubercul...
متن کاملDiscordance in Mycobacterium tuberculosis Rifampin Susceptibility
habitat overlaps with that of pteropid bats in southern Vietnam. Previous studies showed that IgG ELISA results for NiV-positive fl ying foxes correlated well with NT results (3,4). However, in our study, discrepancies existed between NT results and NiV-N-ELISA and WB results. A reason for these differences could be that Nipah-like viruses are circulating among bats in Vietnam, producing antibo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2014
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.02778-14